Congresso Brasileiro de Microbiologia 2023

Congresso Brasileiro de Microbiologia 2023

Resumo: 1429-2

1429-2

FATAL CASE SERIES OF CHIKUNGUNYA VIRUS IN GOIÁS: DESCRIPTION OF CLINICAL CHARACTERISTICS AND CAUSE OF DEATH

Autores:

Ronaldo Rodrigues de Oliveira Junior (UFG - Universidade Federal de Goiás) ; Valéria Christina de Rezende Feres (UFG - Universidade Federal de Goiás) ; Caroline Pires Santana (UFG - Universidade Federal de Goiás) ; Christiane França Martins (UFG - Universidade Federal de Goiás) ; Isabella Ferreira da Costa (UFG - Universidade Federal de Goiás) ; Isabela Cinquini Junqueira (UFG - Universidade Federal de Goiás) ; José Lindomar Pena (FIOCRUZ/PE - Instituto Aggeu Magalhães) ; Nayara Santos de Oliveira (SMS - GO - Secretaria Municipal de Saúde de Goiânia) ; Yves Mauro Fernandes Ternes (SMS - GO - Secretaria Municipal de Saúde de Goiânia)

Resumo:

The Midwest region of Brazil has been showing a significant increase in the number of confirmed cases and deaths due to Chikungunya fever in the last two years, since the introduction of the Chikungunya virus (CHIKV) in Brazil in 2014. The aim of this study was to describe a series of six CHIKV-related deaths in Goiás, between 2015 and 2022. This is a retrospective case series from a database created through deterministic linkage between the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação - SINAN) and the Mortality Information System (Sistema de Informação sobre Mortalidade - SIM). R software version 2022.12.0+353 was used to create the database. From this, six records with laboratory confirmation by serology (IgM) and/or molecular diagnosis were selected. The deaths occurred in the years 2016 and 2022, comprising four females and two males. Among them, four were young adults (20 to 36 years old), and two were 54 and 68 years old. Out of the total, three women had comorbidities, while only one man did. All individuals presented the classic symptoms of Chikungunya fever, although arthritis (a pathognomonic sign) was less frequent. It was observed that patient progression from symptom onset to death occurred in different periods: three patients passed away after more than 20 days, and the other three between two to six days. Patients with a longer interval of days developed severe respiratory complications and sepsis. Those with a shorter interval of days progressed directly to the terminal condition, except for one patient whose condition evolved into pulmonary and cerebral edema and subsequently sepsis. These findings suggest a link between initial CHIKV infection and the severe progression of respiratory conditions and/or sepsis leading to a fatal outcome. They also show deaths in the acute phase and deaths in the convalescent phase. Therefore, further investigation is needed into the immunological status of patients with a longer duration.

Palavras-chave:

Chikungunya virus, Epidemiology, Fatal cases, Health database, Record linkage

Agência de fomento:

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes), Cons Nac de Desenv Científico e Tecnologia (CNPq), Faculdade de Farmácia (UFG), Secretaria Municipal de Saúde, Secretaria Estadual de Saúde, Instituto Aggeu Magalhães (FIOCRUZ-PE)